Transplacental transfer and metabolism of bupropion
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چکیده
منابع مشابه
Transplacental transfer and metabolism of buprenorphine.
Information on the direct and indirect effects of buprenorphine (BUP) on the fetus is essential for determining its potential for treatment of the pregnant opiate addict. The goal of this investigation is to determine the transplacental transfer of BUP to the fetal circulation, its metabolism, and effects on the tissue. The technique of dual perfusion of placental lobule is used. The range of B...
متن کاملTransplacental transfer of genotoxins and transplacental carcinogenesis.
A number of chemical compounds induce cancer in the offspring of animals treated with these compounds. The fetus is sensitive to the toxic and teratogenic effects of chemicals in the early embryonic stages, whereas it is sensitive to carcinogenic effects during late fetal stages. Carcinogens may be direct acting or may require metabolic oxidation such as those in tobacco smoke. Activation can o...
متن کاملStereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4′-OH-bupropion in vitro
Bupropion is a widely used antidepressant, smoking cessation aid, and weight-loss therapy. It is administered as a racemic mixture, but the pharmacokinetics and activity of bupropion are stereoselective. The activity and side effects of bupropion are attributed to bupropion and its metabolites S,S- and R,R-OH-bupropion, threohydrobupropion, and erythrohydrobupropion. Yet the stereoselective met...
متن کاملThe Metabolism and Transplacental Transfer of Oseltamivir in the Ex Vivo Human Model
UNLABELLED Oseltamivir phosphate is extensively metabolized in the ex vivo human placenta model, and the transplacental passage of the metabolite oseltamivir carboxylate is incomplete. OBJECTIVE To evaluate the metabolism and transplacental transfer of oseltamivir (Tamiflu) in the ex vivo human placental model. STUDY DESIGN Perfusion studies were performed in six placentas from term, uncomp...
متن کاملMetabolism and disposition of bupropion in pregnant baboons (Papio cynocephalus).
Recent in vitro data obtained in our laboratory revealed similarities between baboons and humans in the biotransformation of bupropion (BUP) by both hepatic and placental microsomes. These data supported the use of baboons to study BUP biotransformation during pregnancy. The aim of this investigation was to determine the pharmacokinetics of BUP in baboons during pregnancy and postpartum, as wel...
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ژورنال
عنوان ژورنال: The Journal of Maternal-Fetal & Neonatal Medicine
سال: 2009
ISSN: 1476-7058
DOI: 10.1080/14767050903168424